American Society of Hematology

Figure 1.

$Figure 1. Numbers of CFU progenitor cells in patients with MDS and in controls. Numbers of circulating CFU-GM cells (left panel) and BFU-E cells (right panel) were determined in a methylcellulose assay. Peripheral blood mononuclear cells were plated on day 0 and cultured for 14 days in the presence of cytokines (IL-3, GM-CSF, and EPO). Colonies were counted under an inverted microscope. Results show the numbers of CFUs/BFUs/μL blood and represent the ranges (bars), 50 percentile values (boxes), and median values (horizontal lines within boxes) in each group of patients (10-15 patients per group). The grey area indicates the normal range of CFU-GM and BFU-E cells. All investigations were performed within (as part of) the routine examination of cytopenic patients at the Medical University of Vienna. AIHA indicates autoimmune hemolytic anemia; RA, refractory anemia; RARS, RA with ring sideroblasts; and RAEB, RA with excess blasts.$

Numbers of CFU progenitor cells in patients with MDS and in controls. Numbers of circulating CFU-GM cells (left panel) and BFU-E cells (right panel) were determined in a methylcellulose assay. Peripheral blood mononuclear cells were plated on day 0 and cultured for 14 days in the presence of cytokines (IL-3, GM-CSF, and EPO). Colonies were counted under an inverted microscope. Results show the numbers of CFUs/BFUs/μL blood and represent the ranges (bars), 50 percentile values (boxes), and median values (horizontal lines within boxes) in each group of patients (10-15 patients per group). The grey area indicates the normal range of CFU-GM and BFU-E cells. All investigations were performed within (as part of) the routine examination of cytopenic patients at the Medical University of Vienna. AIHA indicates autoimmune hemolytic anemia; RA, refractory anemia; RARS, RA with ring sideroblasts; and RAEB, RA with excess blasts.

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