Signaling pathways elucidated by NGS in CLL. Nine genes with significant mutation frequencies identified by Wang et al³¹  fall into 5 core signaling pathways in which the genes play well-established roles: DNA damage repair and cell cycle control (A), Notch signaling (B), inflammatory pathways (C), Wnt signaling (D), and RNA splicing and processing (E). Genes with significant mutation frequencies are shown in red, and genes with mutations that are in a signaling pathway related to CLL are shown in pink. Used with permission from Wang et al.³¹