Waterfall and swimmers plots. (A) Percentage change in tumor burden. The waterfall plot depicts the percentage change in tumor volume at the time of best response for 20 evaluable patients in the phase 1 population and the 5 exploratory patients with T-cell lymphoma (inset). Three patients had evaluable, but not measurable disease: 1 patient had CD8⁺ cutaneous peripheral T-cell lymphoma, 1 had cutaneous anaplastic large cell lymphoma, and 1 had cutaneous diffuse large B-cell lymphoma; all achieved a partial response. Each bar represents an individual patient. Asterisks indicate CR. The 3 leftmost bars of the main plot represent patients whose tumor size increased by 100% or more. (B) Duration of response. For patients who underwent stem cell transplantation, the duration of response was censored at the time of this procedure. the figure highlights how the responder population is enriched in patients with T-cell lymphoma who may also exhibit longer lasting responses to the combination of 5-AZA and ROMI compared with their non–T-cell lymphoma counterparts.