Treatment with RvD1, RvD4, LXA4, and MaR1 enhances thrombus resolution in mice. (A) Temporal distribution of RvD1, RvD4, and MaR1 in the thrombus during DVT in mice. Results are expressed in picograms of SPM/10 mg of thrombus and are representative of a pool of 3 thrombi. (B) Representative Doppler ultrasonography images of IVC thrombi obtained from the same mouse at the indicated points after IVC stenosis induction. The red represents arterial flow, the blue is venous flow, and the thrombus is outlined in cyan. Scale bars, 2.5 mm. (C) Relative thrombus length. Thrombus size was monitored by ultrasonography on day 1, day 4, and day 8 postsurgery. n = 7 mice in the vehicle-treated group (●), and n = 9 in the SPM mix-treated group (▪). *P < .05; **P < .01, with 2-tailed unpaired t test for vehicle vs SPM. (D) Network pathway visualization of the LMs in the thrombus after SPM treatment. Node size represents the amount of LM (pg/10 mg of thrombus) in the thrombus after SPM treatment. Node color represents the fold change (compared with vehicle treatment).