Genetic defects detected by WES and SNP-array analysis. (A) Overview; for each patient, all mutations in genes known to be recurrently mutated in myeloid malignancies detected by WES are depicted as well as cytogenetic abnormalities detected by SNP array analysis. 2 = 2 mutations were detected. (B) Number of acquired mutations per patient as determined by WES. In black is the number of mutations in genes that have been previously implicated in pathogenesis of myeloid malignancies; in gray is the number of mutations in genes that have not been previously implicated in myeloid malignancies. (C) Correlation between age and the number of mutations. (D) Distribution of the various types of alterations detected in the total set of patients with RS phenotype. (E) SNP array results overview; figure was created using Nexus software. Red, loss; blue, gain.