Comutations vary by blast phenotype in AML with mutated NPM1.TET2 and IDH1/2 comutations are significantly more frequent in cases with a DN blast phenotype (P < .0001 comparing all 3 groups), whereas DNMT3A mutations are significantly less common in this group (P = .002 comparing all 3 groups). RAS pathway mutations included NRAS, KRAS, CBL, and PTPN11 mutations. **P < .01, ***P < .0001.