Correlation between NPM1 and comutation VAFs. (A) Box and whisker plots show VAFs at diagnosis for NPM1 and the most common comutations (n = 199). (B) Scatter plots showing the correlation between NPM1 VAF and TET2 and IDH1/2 VAFs in cases with DN (n = 61), monocytic (n = 40), and myeloid (n = 22) immunophenotypes.