Analysis of RT abnormalities of TCF3-PBX1–positive cells. (A) Hierarchical analysis of RT signature 1 from Figure 3 that clusters TCF3-PBX1–positive cells with normal B cells. This RT signature can be subclassified in 3 RT subsignatures. (B) RT signature 1A: TCF3-PBX1–specific RT changes that track with normal pre-B cells (late B-precursors; CD34^–CD19⁺ROR1⁺ cells). RT signature 1B: TCF3-PBX1–specific RT changes that track with Epstein-Barr virus immortalizedB cells. RT signature 1C: TCF3-PBX1–specific RT changes that do not track with any of the B cells and serve to substratify patient samples. (C) TCF3-PBX1–positive patient cells retain altered early replication of ROR1 from normal late B-precursors.