Plasma TFPI levels in 5 F5F8D patients. Total and free TFPI antigen levels of F5F8D patients were measured and compared with groups of severe FVD patients, mild FVD patients, and normal controls. (A) Total TFPI antigen levels. (B) Free TFPI antigen levels. The horizontal lines represent the means of the respective groups. *P < .05, **P < .01. FVD, FV-deficient patients.