Effect of normalized FV or FVIII on thrombin generation in 4 F5F8D PRPs. (A) Thrombin generation in PRP of 4 F5F8D patients. (B) Thrombin generation in 4 F5F8D PRPs with addition of FV to bring the FV level to 100 IU/dL. (C) Thrombin generation in 4 F5F8D PRPs with addition of FVIII to bring the FVIII level to 100 IU/dL. (D) Thrombin generation in PRP of 4 F5F8D patients received 0.5 hour after DDAVP infusion. The average TGA curve of 10 normal PRPs is presented for reference. (E) PH values of thrombin generation were compared among the different groups mentioned above. *P < .05.