Platelets promote lymphangiogenesis after wounding. (A) Schematic of PRP or PPP treatment to tail injury. After lymphatic injury in the recipient mouse, the injury site is cleaned and PRP or PPP prepared from blood from a donor mouse added. (B) Images showing application of PRP or PPP to the tail injury site. (C) Representative tail lymphangiography across the injury site on day 7 after tail lymphatic injury in wild-type mice to which PRP or PPP was added to the injury site. Note that flow across collecting lymphatic vessels is not restored in the PPP-treated animal, but is restored in the PRP-treated animal (yellow arrow). (D) Healing curves for restoration of lymphatic flow after addition of PRP or PPP to the injury site. Scale bars = 500 µm. *P < .05.