Overexpression of miR-10a inhibited cell proliferation and induced apoptosis in MM-BMSCs. Expression levels of miR-10a (A), miR-346 (B), and miR-135b (C) in BMSCs after transfection with the respective mimics, measured by using quantitative reverse transcription-polymerase chain reaction. Data represent fold increase compared with control (Nega-miR) ± standard deviation. Cell viability 72 hours after transfection with miR-10a (D), miR-346 (E), and miR-135b (F) mimics. Values represent proliferation rates normalized by control (with Nega-miR) ± standard deviation. (G) Caspase-3/7 activity in normal-BMSCs and MM-BMSCs transfected with 10 nM of miR-10a mimic for 72 hours. Data represent fold increases compared with control (with Nega-miR) ± standard deviation. *P < .01 vs control (with Nega-miR). (H) Time course of apoptosis induced by miR-10a transfection in MM-BMSCs determined by Annexin V and PI staining and flow cytometry.