Upregulation of TAZ sensitizes MM cells to chemotherapeutics. KMM1 (A) and JJN3 (B) cells were treated with increasing concentrations of DAC for 48 hours followed by exposure to BTZ for 72 hours before cell viability was assessed. CI values were calculated using CompuSyn software. Immunoblot analysis of TAZ and MYC expression in KMM1 (C) and JJN3 (D) cells treated with DAC for 48 hours followed by BTZ exposure for 24 hours. KMM1 (E) and JJN3 (F) cells were treated with increasing concentration of DAC for 48 hours followed by exposure to TSA for 72 hours before cell viability was assessed and CI values calculated. Immunoblot analysis of TAZ and MYC expression in KMM1 (G) and JJN3 (H) cells treated with DAC for 48 hours followed by TSA exposure for 24 hours. Densitometry was performed and relative expression, normalized to β-actin, is shown below the lanes indicating expression compared with untreated cells. ns, nonspecific.