WES and RNA-seq. (A) Distribution of the chromosomal aberrations and mutations in the 3 cytogenetic subgroups (MYC translocation, MYC gain, and no MYC aberration) in the 16 cases analyzed by using WES. Chromosomal abnormalities: gray, absence; color, presence. Mutations: gray, wild type; color, mutated. (B) Principal component analysis of differential gene expression patterns for 12 samples with various cytogenetic abnormalities.