Schematic diagram of a practical approach to the management of cytopenias in immune dysregulatory disorders. APDS, activated phosphatidylinositol 3-kinase δ syndrome; CBC, complete blood count; DAT, direct antiglobulin test; GOF, gain-of-function; IgG, immunoglobulin G; IV, intravenous; MMF, mycophenolate mofetil; NK, natural killer; PASLI, p110 delta-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency; PIK3CD, phosphatidylnositol 3-kinase C delta.