Example of management scheme for SCD in children in high-resource countries. ACS, acute chest syndrome; CBC, complete blood count; CT, computed tomography; DHTR, delayed hemolytic transfusion reaction; HSCT, hematopoietic stem cell transplantation; MRI, magnetic resonance imaging; PID, preimplantation diagnosis; PND, prenatal diagnosis; SCD; sickle cell disease; TCD, transcranial Doppler ultrasonography; VOC, vaso-occlusive crisis.