Clonality of genetic drivers in the primary cHLs. CCFs of genetic alterations (≥2 within the cohort). The alterations are ranked by the median CCF indicated as red bar (left to right, high to low), error bars, and interquartile range. Mutations, black; copy number (CN) gain, red; CN loss, blue; SVs, green. The staggered bar graph in the lower panel categorizes the alterations in percentage of clonal and subclonal alterations; the threshold for clonal alterations is a CCF of ≥0.9.