Figure 7.
Erythropoiesis is impaired in human cohesin-mutated myelodysplastic syndromes and acute myeloid leukemia. (A) Differential gene expression in STAG2 mutated MDS vs all other MDS subtypes. Only events with FDR q < 0.1 are shown. The red (enriched in other MDS) and black (enriched in shSTAG2mut MDS) segments specify for log2FC > 0.5 differential genes. Genes of interest are shown. (B) NES for significant hematopoiesis-related datasets (FDR < 0.05) as determined by GSEA. Input was a ranked list of all genes from panel A. STAG2 mutant-enriched gene sets are to the right of 0 and other MDS subtype gene sets to the left. Common and exclusive mutations of the indicated genes among 3612 myeloid neoplasia curated by the (C) Cosmic database and 3256 AML samples from the (D) UK National Cancer Research Institute AML trials (2434 samples), BEAT-AML (622), and TCGA LAML (200) datasets.

Erythropoiesis is impaired in human cohesin-mutated myelodysplastic syndromes and acute myeloid leukemia. (A) Differential gene expression in STAG2 mutated MDS vs all other MDS subtypes. Only events with FDR q < 0.1 are shown. The red (enriched in other MDS) and black (enriched in shSTAG2mut MDS) segments specify for log2FC > 0.5 differential genes. Genes of interest are shown. (B) NES for significant hematopoiesis-related datasets (FDR < 0.05) as determined by GSEA. Input was a ranked list of all genes from panel A. STAG2 mutant-enriched gene sets are to the right of 0 and other MDS subtype gene sets to the left. Common and exclusive mutations of the indicated genes among 3612 myeloid neoplasia curated by the (C) Cosmic database and 3256 AML samples from the (D) UK National Cancer Research Institute AML trials (2434 samples), BEAT-AML (622), and TCGA LAML (200) datasets.

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