Scatter plot of logarithmic transformations of observed vs predicted numbers of adult NPM1 4-bp insertion/duplication mutations at c.863_864. From a cohort of 2257 independent mutations showing significant correlation between observed and predicted values. Each diamond represents 1 of the 122 possible mutations. Observed counts of 0 were substituted with the predicted occurrence of the rarest mutation to allow logarithmic transformation. Red diamonds: 2 most overrepresented mutations, c.863_844insCATG and c.863_844insCAGA. Yellow diamonds: 10 mutations predicted to occur 2 to 27 times in the cohort, but not observed.