Antioxidant profiles of MDS/sAML patients. Expression levels of 28 transcripts of key antioxidant genes in the BM of patients MDS/sAML. Transcripts are ranked in decreasing order of expression in normal BM. Results are expressed as relative quantification (RQ) compared with normal BM (mean ± SEM). The horizontal black line (y = 1) represents the healthy control profile (n = 16), and green, yellow, and red lines represent patients’ data (thick and thin lines representing mean and SEM, respectively). The gray area corresponds to variations less than twice that of controls. Dashed vertical lines indicate variants with at least 1 significant difference between patients and healthy controls. MDS with <5% blasts (MDS-SLD and MDS-MLD) display an overexpression of only a few low-expressed transcripts (GLRX family), conversely to MDS with 5% to 19% blasts (MDS-EB-1 and MDS-EB-2), showing several overexpressions (PRDX and GPX families). The profile of sAML was different, with decreased expression of 6 transcripts, especially PRDX2 or GPX3. Significant difference with the healthy controls (ΔCt values), *P < .05; #P < .01.