Clinical response to ibrutinib-based combination therapy in CNSL. (A) Best response to ibrutinib-based combination therapy. Displayed is the change in target lesion diameter from baseline (%) by MRI or clearance of malignant cells in CSF; negative values indicate tumor shrinkage. Eight of 9 (89%) PCNSL patients and 4 of 6 (67%) SCNSL patients responded to ibrutinib-based combination therapy. (B) PFS in patients with PCNSL (upper panel) and SCNSL (lower panel).