Distribution of genomic aberrations in HHV8-negative EBL. Each column represents an individual case (HHV8-negative EBL 001-008). Rows depict genomic aberrations, including mutations, CNAs, and translocations. The bar graph on the right shows the percentage of each aberration in the full cohort. Variant categories include missense mutations (gray), truncating mutations (black), low-level copy number gains (red), high-level copy number gains (dark red), low-level copy number losses (blue), high-level copy number losses (dark blue), translocations with immunoglobulin (Ig) partners (dark green), and translocations with non–immunoglobulin partners (light green). Freq., frequency.