DACH1 deletion in hepatocytes increases bleeding time and time to thrombotic carotid occlusion in mice. (A) Tail bleeding time and representative images of bleeding patterns on filter paper. Black arrows indicate beginning bleeding time course, and red arrows depict episodes of rebleeding. Time to occlusive carotid arterial thrombosis induced by 10% FeCl₃ injury (B) or Rose bengal/laser photochemical injury (C). (B) Representative blood flow pattern. The red arrows depict rapid increases in blood flow after transient occlusions, suggestive of transient recanalization of the clotted vessel. **P < .01, 2-tailed Student t test (n = 8-10 mice per group).