Coadministration of Met restored myocardial dysfunction without affecting Cfz proteasomal inhibitory activity. (A) Proteasomal activity in myocardial tissue in experimental protocols 6A and 6B. (B) Proteasomal activity in PBMCs in experimental protocols 6A and 6B. (C) Representative echocardiographic M-mode images of protocol 6A at baseline and end point. (D) Representative echocardiographic M-mode images of protocol 6B at baseline and end point. (E) FS% graph of protocol 6A (circles, individual values). (F) FS% graph of protocol 6B (circles, individual values). *P < .05, **P < .01, ***P = .001, ****P < .0001.