Lack of increase in intrahepatic fibrin(ogen) deposition after resection corresponds with LD following liver resection in humans. Liver biopsy specimens were obtained from 11 patients before resection (before) and 2 hours after ligation of the portal vein (postresection) and stained for fibrin(ogen). (A) Changes in intrahepatic fibrin(ogen) deposition before the surgery and postresection. (B) Individual changes in intrahepatic fibrin(ogen) deposition before (open circles) and post-resection (open squares) between patients who did (LD, n = 6) or did not (no LD, n = 5) suffer from postoperative LD. (C) Representative images of intrahepatic fibrin(ogen) immunohistochemical staining in liver biopsy specimens obtained before surgery (upper panels) or postresection (lower panels). Left panels show images of liver biopsy specimens taken from a patient who did not develop LD. Right panels show images of liver biopsy specimens taken from a patient who developed postresection LD. (D) The fold change (percent positive pixels postresection divided by percent positive pixels before) in intrahepatic fibrin(ogen) deposition in patients who did not develop LD (no LD) following PHx and patients who did (LD). Intrahepatic fibrin(ogen) deposition is expressed as percent positive pixels, and individual patients are plotted in panels A, B, and D. Dashed lines connect individual changes in intrahepatic fibrin(ogen) deposition before and after resection. *P < .05.