LIC change in non–transfusion-dependent (A) and transfusion-dependent β-thalassemia patients (B). Each filled circle represents 1 patient’s baseline LIC; each line represents the best recorded change in LIC post baseline. Only patients with ≥4 months postbaseline LIC are included. Patients noted to have received iron chelation therapy could have received it in the 84 days before treatment as well as on study. dw, dry weight.