Glycan expression on plasma-derived VWF demonstrates marked heterogeneity in healthy controls. Using SNA-, MAL-II–, WGA-, RCA-I–, ECA-, and UEA-1–modified lectin plate-binding assays, pdVWF glycosylation profiles were examined in a cohort of 68 healthy volunteer blood donors. All ELISAs were performed in duplicate and results expressed as a percentage of binding to reference plasma.