Figure 1.
![Figure 1. Severe myelofibrosis and osteosclerosis develop in VDR−/− mice transplanted with VDR+/+ BM (basic model). (A) Survival and blood analyses (donor chimerism, WBC count, hemoglobin [Hb], and platelet count) in VDR+/+ and VDR−/− recipient mice transplanted with VDR+/+ BM. (B-D) Femur sections of VDR+/+ and VDR−/− recipient mice transplanted with VDR+/+ BM (2 months after transplantation): (B) H&E staining, (C) micro-CT, and (D) silver staining. Scale bars, 500 μm (black) and 50 μm (white). Representative pictures or combined data of at least 3 independent experiments are shown. Data are represented as mean plus or minus SEM. **P < .01, ***P < .001 (Kaplan-Meier analysis and Student t test).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/133/15/10.1182_blood-2018-09-876615/3/blood876615f1.png?Expires=1735508841&Signature=ZailSsjBACsL8fAhZwydrc4nmlIFKZf6ptTjbusvmbd~3op0zq~cvjIq3361IpqDiYRRtKu5lLDg2uFo2nVmF4S~OEEyV43JTYsfgqZgh64cemNVAIYRTV880~MbH6pZEWyyDozS-hIa~i~osijBicWsEyc5lD8rKBMoIEPAjzoyrLNxOw8h7B-2AMx03ydOICcgQbVy~AkbwK8l9KQP1HHixi2-C3Net3cjcFmudJa0RnXSqY5UIJbzoLwhatypCMNyIlVye0LknzeFn5NjPHMQsdXIWpL7FsWugDaM5pBymLqzQDsL-I8Y6CMmGRVGvxoSkBb8aaBRMFjxjs8zCw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Severe myelofibrosis and osteosclerosis develop in VDR−/− mice transplanted with VDR+/+ BM (basic model). (A) Survival and blood analyses (donor chimerism, WBC count, hemoglobin [Hb], and platelet count) in VDR+/+ and VDR−/− recipient mice transplanted with VDR+/+ BM. (B-D) Femur sections of VDR+/+ and VDR−/− recipient mice transplanted with VDR+/+ BM (2 months after transplantation): (B) H&E staining, (C) micro-CT, and (D) silver staining. Scale bars, 500 μm (black) and 50 μm (white). Representative pictures or combined data of at least 3 independent experiments are shown. Data are represented as mean plus or minus SEM. **P < .01, ***P < .001 (Kaplan-Meier analysis and Student t test).