Altered composition of the hematopoietic stem and progenitor cells upon Cdk6 ablation in JAK2^V617Fmutant BM. Mice were euthanized at 8 weeks of age. (A-D) Total numbers of HSCs and progenitors per 1 × 10⁶ BM cells are shown. Error bars indicate + SD. *P < .05; **P < .01; ***P < .001; ****P < .0001. The group sizes were n ≥ 10 per genotype. CMP (common myeloid progenitor), LKS⁻CD34^intCD16/32^int; GMP (granulocyte/macrophage progenitor): LKS⁻CD34⁺CD16/32⁺; LT-HSC, CD150⁺CD48⁻LSK; MEP (megakaryocyte/erythroid progenitor): LKS⁻CD34⁻CD16/32⁻. (E-F) Overview of distribution of HSCs (E) and myeloid progenitors (F) in BM. Chart size corresponds to absolute numbers of LSK (E) and LKS⁻ (F) cells in mice of respective genotype.