Altered composition of the myeloid lineages upon Cdk6 ablation in JAK2^V617Fmutant mice. Mice were euthanized at 8 weeks of age (n ≥ 10 per genotype). (A-B) Total numbers of indicated lineages per 1 × 10⁶ BM (A) and splenic cells (B) are shown. Error bars indicate + SD * P < .05; **P < .01; ****P < .0001. (C) Frequencies of indicated lineages in PB cells from mice used in panels A and B are depicted. Results are presented as means + SD *P < .05. (D) Percentage of indicated myeloid populations in PB is shown. Error bars indicate + standard error of the mean. n ≥ 3 per genotype; monocytes MHCII⁻CD11b⁺CD115⁺Ly6C⁻; neutrophils CD11b⁺Ly6G⁺Ly6C^lowCD11c⁻CD115⁻CD170⁻; eosinophils CD11b⁺Ly6G⁻Ly6C^midCD11c⁻.