IdeS prevents thrombocytopenia and thrombin generation induced by 5B9 in vivo. (A) Relative decrease in platelet count compared with day 0 after injection of UFH in transgenic 5B9-treated mice (hFcγRIIA, hPF4 transgenic, mPF4 knockout) having received IdeS (25 U/g; n = 3) or PBS (n = 3). (B) TAT levels on days 0, 1, and 2. Data are mean ± SEM. *P < .05.