Genomic region 7 kb downstream of human CEBPE TSS is orthologous to the murine +6-kb enhancer. (A) Analysis of publicly available data reveals an open chromatin region 7 kb downstream of CEBPE TSS that is also flanked by CTCF binding and enriched for P300 signal in NB4 cells.²⁷  The region also harbors binding of hematopoietic TFs RUNX1, FLI1, and LYL1 (highlighted). (B) ChIP-seq tracks for TFs occupying the +7-kb region in Kasumi-1 cells (highlighted).^38,39  (C) ChIP-seq track depicts occupancy of CEBPE at the +7-kb region in NB4 cells (highlighted).