TFR monitoring based on the NCCN guidelines and potential monitoring strategies. (A) Algorithm A: based on NCCN guidelines. Monitoring regime as recommended by the NCCN, monthly testing for the first 12 months of a TFR attempt (12 tests for all patients). (B) Algorithm B commences monthly testing at month 2 for the first 6 months post-TKI cessation followed by monitoring every 2 months between 6 and 12 months. (C) Algorithm C commences testing every 2 months for the first 6 months post-TKI cessation followed by 3-monthly monitoring. (D) Algorithm D maintains 3-monthly testing throughout the TFR attempt. All algorithms incorporate monthly testing following loss of MR4.5.