Plasma MIP-2 or IL-6 levels do not change upon OPN-mediated TRALI induction or prevention. Plasma MIP-2 levels (A-B) or IL-6 levels (C-D) in C57BL/6 OPN KO (A,C) or C57BL/6 WT mice (B,D) primed with LPS, depleted of CD4⁺ T cells and injected with anti-MHC class I antibodies (clones 34-1-2s and AF6-88.5.5.3) and either with PBS or OPN (A,C) or isotype control antibody or anti-OPN antibody (B,D). For statistical analyses, only significant comparisons of interest are shown. Statistical analysis was performed with 1-way ANOVA with a Tukey post hoc test. Each dot represents 1 mouse, and error bars represent SD. *P < .05, **P < .01, ***P < .001, ****P < .0001.