Confirmed clinical response. (A) ORR for all patients and by dose. (B) ORR for subgroups. ^aIndicates data representing dose-escalation cohort (n = 9) and expansion cohort (n = 22) combined. Bor, bortezomib; Car, carfilzomib; Len, lenalidomide; sCR, stringent complete response; VGPR, very good partial response.