Combined Bcl-2 and NF-κB inhibition HE-morphologically blocks proliferation and induces cell death specifically within CTCL tumors in vivo. SeAx xenograft tumors growing intradermally in NSG mice that were treated as described under Figure 4 were used (A) Representative H&E-stained specimens of primary SeAx tumors from the vehicle control and the combination group (upper panels 20x, lower panels 200x). Red arrows mark necrotic areas. (B) Semiquantitative score of necrotic areas in the primary SeAx xenograft tumors (0% to 25% tumor area covered by necrosis = 0; 25% to 50% tumor area covered by necrosis = 1; 50% to 75% tumor area covered by necrosis = 2; 75% to 100% tumor area covered by necrosis = 3). (C) Quantification of the mitosis count per view under 200x magnification in the 4 treatment groups.