Combined Bcl-2 and NF-κB inhibition blocks proliferation and induces apoptosis specifically within CTCL tumors in vivo in immunohistochemistry. (A) Representative specimens of primary SeAx tumors from the vehicle control and the combination group. Immunohistochemical detection of cellular positivity for the proliferation marker Ki-67 (×400). (B) Quantification of the Ki-67⁺ cell count per view under ×400 magnification in the 4 treatment groups. (C) Representative specimens of primary SeAx tumors from the vehicle control and the combination group. Immunohistochemical detection of cellular positivity for cleaved caspase-3 as a readout for apoptotic activity (×400). (D) Quantification of the cleaved caspase-3-positive cell count per view under ×400 magnification in the 4 treatment groups.