Abnormal bone marrow histology and CBCs in patients with ETV6-related thrombocytopenia and leukemia predisposition. (A) Abnormal cellular features (yellow arrows) with hyperchromatic small megakaryocytes, disseminated toxic granulations, and dysplastic eosinophils (magnification ×100; Wright-Giemsa stain). (B) Platelet count, white blood cell (WBC) count, hemoglobin (Hgb), mean cell volume (MCV), and mean platelet volume (MPV) in patients (PT) with germ line mutations in ETV6, as compared with related individuals (Rel) without mutation (Student t test).^3-6,9,10