Epityping of CLL patients from 4 independent sample cohorts using Me-iPLEX. (A) Distribution of the calibrated epitype calls within each of the cohorts. (B) Unsupervised clustering of Me-iPLEX data from CLL samples from 4 independent test cohorts (circles, n = 1286) and from the combined reference cohort (squares, n = 305) using t-SNE.