Platelet HYAL2 regulates serum inflammatory cytokines and inflammatory leukocyte infiltration in mice with DSS-induced colitis. Serum isolated from DSS-treated and control mice at 7 days was tested for (A) TNF-α and (B) IL-6 by using an enzyme-linked immunosorbent assay. (C) F4/80-positive area expressed as the percentage of total area. (D) Ly6G-positive area expressed as the percentage of total area. (E) MPO activity was measured in distal colon lysates of untreated and DSS-treated mice with or without platelet transfusion at 7 days. Data are reported as mean ± SEM; n = 10 mice per group. *P < .05; **P < .01; ***P < .001.