Immunophenotype of 19-28z CAR T-cell products infused and relationship to events (progression or death) and toxicity. Open circles represent data points for each subjects’ graft products’ immunophenotype proportion. (A) Events. Subjects whose infused CAR T cells were composed of a greater percentage of naive-like (CD45RA⁺, CCR7⁺) cells were more likely to experience an event for both CD4⁺ (P = .02) and CD8⁺ (P = .04) CAR⁺ subsets. No significant difference was seen in other immunophenotypic subsets: central memory (CD45RA⁻, CCR7⁺), effector memory (CD45RA⁻, CCR7⁻), and effector (CD45RA⁺, CCR7⁻) T cells. (B) Toxicity. No significant differences were seen in any immunophenotypic subsets of the 19-28z CAR T graft product between subjects who did or did not experience toxicity.