Genetic variations in hematopoietic transcription factors contribute to the inherited risk of developing ALL. This diagram shows transcriptional factor genes in which germline genetic variation have been associated with ALL risk (eg, common polymorphisms linked to ALL susceptibility and rare variants linked to familial predisposition to ALL). The transcriptional factors are drawn largely according to the hematopoietic developmental stage at which they are known to operate. CLP, common lymphoid progenitor; DCs, dendritic cells; HSC, hematopoietic stem cell; ILCs, innate lymphoid cells; NK, natural killer cells; pre-B, pre-B cell; pro-B, pro-B cell.