Distribution of myeloid neoplasms discussed in Zheng et al based on the current classification vs genetic pathway alterations revealed in the study. (A) Venn diagram of current (2016) WHO classification reflecting associations with leukocytosis, dysplasia, or monocytosis. Currently, monocytosis supersedes other features in determining a diagnosis of CMML, whereas granulocytic dysplasia (with left-shift) is the main feature distinguishing atypical CML (aCML), BCR-ABL1 negative from CNL. (B) A proposed Venn diagram showing the association of these disease subtypes with pathway mutations. There is significant overlap between entities that are considered distinct in the WHO classification, yet CNL and the MDS/MPN diseases remain largely separate from MDS and from the other “pure” MPN: essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (MF). MDS/MPN-U, MDS/MPN, unclassifiable. Panel B has been adapted from Figure 2D in the article by Zhang et al that begins on page 867.