ECOG performance status score, CCI, comorbidity count, and cytokine associations with CH. (A) Univariate logistic regression ORs with 95% confidence intervals (CIs) and Benjamini-Hochberg false discovery rate (FDR)–adjusted P values or Bonferroni-adjusted P values, after necessary age adjustment for CH N = 83 (vs no CH N = 276), and CH subtypes (CH_VAF>0.1, N = 36 vs 323; CH_TET2, N = 34 vs 325; CH_DNMT3A, N = 32 vs 327; CH_mut>1, N = 11 vs 348). ECOG performance status score (where a higher score means poorer functioning); CCI (where a higher score means lower predicted 10-year survival); Any comorbidity count, among myocardial infarction, angina/coronary artery bypass graft, congestive heart failure, peripheral vascular disease, cerebrovascular disease, valvular heart disease, arrhythmia, deep vein thrombosis/pulmonary embolism, peptic ulcer disease, GERD, diabetes with/without end organ damage, renal disease, liver disease, chronic pulmonary disease (symptomatic/asymptomatic), rheumatic disease, arthritis. (B) IL-6, IL-8, and TNF-α cytokine levels quantified by multiplex cytokine array on blood serum, min-max normalized (0-100), and plotted with medians ± interquartile range by CH status. P values from Mann-Whitney U tests.