Baseline and follow-up plain radiography of the left lower extremity (femur) of patient 3. (A) Before HSCT, highly increased bone density with significantly diminished radiograph transparency, “ballooning,” especially of the distal femoral diaphysis, and meta/epiphysis. Transversal intraosseous dense horizontal lines are seen. (B) About 4 years after HSCT regression/normalization of bone density, however, decreased cortical lining and even increased osseous “ballooning” is seen. (C) About 8 years after HSCT, remodeling of bone size and complete normalization of cortical thickness is seen.