Overview of eicosanoids and oxylipins in the supernatants of RBCs stored for 5 and 42 days and in the plasma of autologous recipients pre- and posttransfusion of the same units. (A) Outline of eicosanoid and oxylipin metabolism. (B) Levels of eicosanoids in RBC supernatants at 5 and 42 days. (C) Levels of eicosanoids in autologous recipient plasma. ***P < .001; ****P < .0001 (2-tailed paired Student t test). HPETE, hydroperoxyeicosatetraenoic acid; LT, leukotriene; Oxo-ODE, oxo-octadecadienoic acid; PGE2, prostaglandin E2; PGF2, prostaglandin F2; PGH2, prostaglandin H2; TX, thromboxane.