Figure 1.
Figure 1. LN with mixed RDD disease and LCH in the sinuses, BRAF-V600E mutated. (A-B) Sinus expansion with large RDD histiocytes with emperipolesis and inconspicuously intermixed smaller LCH histiocytes with nuclear groves and eosinophilic cytoplasm (arrowhead) (hematoxylin and eosin stain; original magnification ×1000). (C-D) RDD histiocytes and smaller intermixed LCH cells with nuclear and cytoplasmic S100 staining (immunostain; original magnification ×400 and ×1000, respectively). (E) Sinus LCH disease with clusters of plump cells with CD1a surface and cytoplasmic dot staining (immunostain; original magnification ×400). (F) Low variable Langerin (immunostain; original magnification ×400). (G) Strong BRAF (VE1) staining was seen in both histiocyte cell types (immunostain; original magnification ×1000). (H) Two selected magnified RDD cells with emperipolesis and VE1 granular cytoplasmic staining (immunostain; original magnification ×1000).

LN with mixed RDD disease and LCH in the sinuses, BRAF-V600E mutated. (A-B) Sinus expansion with large RDD histiocytes with emperipolesis and inconspicuously intermixed smaller LCH histiocytes with nuclear groves and eosinophilic cytoplasm (arrowhead) (hematoxylin and eosin stain; original magnification ×1000). (C-D) RDD histiocytes and smaller intermixed LCH cells with nuclear and cytoplasmic S100 staining (immunostain; original magnification ×400 and ×1000, respectively). (E) Sinus LCH disease with clusters of plump cells with CD1a surface and cytoplasmic dot staining (immunostain; original magnification ×400). (F) Low variable Langerin (immunostain; original magnification ×400). (G) Strong BRAF (VE1) staining was seen in both histiocyte cell types (immunostain; original magnification ×1000). (H) Two selected magnified RDD cells with emperipolesis and VE1 granular cytoplasmic staining (immunostain; original magnification ×1000).

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