Statistical analysis of CBM prediction. (A) ROC curve used the DIS, an output from CBM, to generate area under the receiver operating characteristics = 0.9. (B) A Kaplan-Meier–like estimate of digital simulation on the 18 patients treated with HMA. The x-axis measures the predicted DIS, and the y-axis denotes the percentage of patients predicted to achieve the simulated DIS based on disease biology. The blue line represents all patients in the cohort, regardless of genomic aberrations (N = 18); the red line denotes patient profiles that had the genetic signature of WT ASXL1, TET2, or IDH1/2 mutation, and mutant EZH2 (n = 11).