Targeting innate and inflammatory signaling for the treatment of MDS. ASC, apoptosis-associated speck-like protein containing a caspase-recruitment domain; BiTE, bispecific T-cell engager; BTK, Bruton tyrosine kinase; CAR, chimeric antigen receptor; DPI, diphenyleneiodonium; IgG, immunoglobulin G; Inh, inhibitor; NAC, N-acetyl-l-cysteine; neut, neutralize; NLRP3, NOD-like receptor protein 3; NOX, nicotinamide-adenine dinucleotide phosphate oxidase; ROS, reactive oxygen species; TGF, transforming growth factor. Adapted from Sallman et al.⁷⁸  Professional illustration by Somersault18:24.