Major functional pathways newly identified to be affected by somatic mutations. Major functional pathways newly identified as somatic alterations include DNA methylation (A), PRC2 and related genes (B), SFs (C), and the cohesion complex (D). For each panel, major targets of mutations are indicated with functional implications. 5hmc, 5′-hydroxymethylcytosine; 5mc, methylated cytosine; TCA, tricarboxylic acid.